Braliou Georgia

Research

The research of Dr Braliou is focused on two main directions. In the first one which covers mostly Molecular Biology and Biochemistry her focus is on transcriptional regulation of gene expression by molecules that exert their action in the nucleus such as nuclear hormone receptors,  hypoxia inducible factor or other transcription factors and co-factors, to elucidate mechanisms underlying diseases. In the second field, which covers mostly the area of Genetic Epidemiology her interest is in the contribution of genetic polymorphisms in the aetiology of multifactorial human diseases. With the case-control design applied in genetic association studies, she investigates SNPs implicated in the aetiology of diseases. In the same line, she also uses meta-analysis of genetic-association studies and GWASs in an effort to detect weak genotype-disease associations that most case-control studies do not have the power to detect. Finally, molecular biology techniques can be applied to the variants identified in order to elucidate mechanisms that underlie their action.

Projects

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Publications

A1.    Ciana, P., Braliou, G.G., Demay, F., von Lindern, M., Barettino, D., Beug, H. and Stunnenberg, H. ‘Leukemic transformation by the v-ErbA oncoprotein entails constitutive binding to and repression of an erythroid enhancer in vivo’. EMBO Journal, 1998, 17 (24), 7382-7394. (Οι δυο πρώτοι συγγραφείς συμμετείχαν εξίσου). http://emboj.embopress.org/content/17/24/7382.long 

A2.       Braliou, G.G., Ciana, P., Klaassen, W Gandrillon, O. and Stunnenberg, H. ‘The v-ErbA oncoprotein quenches the activity of an erythroid-specific enhancer’. Oncogene, 2001, 20 (7), 775-787. http://www.nature.com/onc/journal/v20/n7/full/1204159a.html

A3.       Braliou, G.G., Venieris, Ε., Kalousi, A., and Simos, G. ‘Reconstitution of human Hypoxia Inducible Factor (HIF-1) in yeast cells: a simple in vivo system to identify and characterize HIF-1α effectors’. Biochemical and Biophysical Research Communications, 2006, 346, 1289-1296. (Οι δυο πρώτοι συγγραφείς συμμετείχαν εξίσου). http://www.sciencedirect.com/science/article/pii/S0006291X06013428

A4.       Brinkman, A.B., Pennings,S.W.C., Braliou, G.G., Rietveld, L.E.G and Stunnenberg, H.G. ‘DNA methylation immediately adjacent to active histone marking does not silence transcription’ Nucleic Acids Research 2007, 35, (3), 801–811.  https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1807972/

A5.       Braliou G.G., Verga Falzacappa M.V., Chachami, G., Casanovas G., Muckenthaler M. U., and Simos, G. ‘2-oxoglutarate-dependent oxygenases control hepcidin gene expression’. Journal of Hepatology 2008, 48, 801-10. http://www.sciencedirect.com/science/article/pii/S0168827808000627

A6.       Chachami, G., Paraskeva, E., Mingot, J.M., Braliou, G.G., Görlich, D., and Simos, G. ‘Transport of hypoxia-inducible factor HIF-1α into the nucleus involves importins 4 and 7’. Biochemical and Biophysical Research Communications, 2009, 390, 235-240. http://www.sciencedirect.com/science/article/pii/S0006291X09019020 

A7.       Braliou GG, Grigoriadou AM, Kontou PI, Bagos PG. ‘The role of genetic polymorphisms of the Renin-Angiotensin System in renal diseases: A meta-analysis’. Computational & Structural Biotechnology Journal, 2014, 10, 1-7. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4151998/ 

A8.       Braliou GG, Pantavou KG, Kontou PI, Bagos PG. ‘Polymorphisms of the CD24 Gene Are Associated with Risk of Multiple Sclerosis: A Meta-Analysis’. International Journal of Molecular Sciences, 2015, 16, 12368-81. (ΙF: 3.765, C:4). https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4490449/

A9.      Pantavou KG, Braliou GG, Kontou PI, Dimou NL, Bagos PG. ‘A meta-analysis of FZD3 gene polymorphisms and their association with schizophrenia’. Psychiatric Genetics. 2016, 26, 272-280. http://journals.lww.com/psychgenetics/pages/articleviewer.aspx?year=2016&issue=12000&article=00004&type=abstract (ΙF: 2.014), (C:9).

A10.    Dimou NL, Pantavou KG, Braliou GG, Bagos PG. ‘Multivariate Methods for Meta-analysis of Genetic Association Studies’. Methods Mol Biol. 2018, 1793:157-182. doi: 10.1007/978-1-4939-7868-7_11. https://link.springer.com/protocol/10.1007%2F978-1-4939-7868-7_11

Α11.    Tsiara CG, Nikolopoulos GK, Dimou NL,  Pantavou KG, Bagos PG, Mensah B, Talias M, Braliou GG, Paraskeva D, Bonovas S, Hatzakis A. ‘Interleukin gene polymorphisms and susceptibility to HIV-1 infection: a meta-analysis’. Journal of Genetics. 2018, 97(1): 235-251 

Α12.    Kontou PI, Pavlopoulou A, Braliou GG, Bogiatzi S, Dimou NL, Bangalore S, Pantelis Bagos PG. ‘Identification of gene expression profiles in myocardial infarction: A systematic review and meta-analysis’. BMC Med Genomics. 2018, 11(1):109 doi: 10.1186/s12920-018-0427-x. 

A13.    #Braliou GG, Kontou PI, Boleti H, Bagos PG. ‘Susceptibility to leishmaniasis is affected by host SLC11A1 gene polymorphisms: a systematic review and meta-analysis’. Parasitol Res. 2019 118(8):2329-2342. doi: 10.1007/s00436-019-06374-y. 

A14.    Kontou PI, Braliou GG, Dimou NL, Nikolopoulos G, Bagos PG ‘Antibody Tests in Detecting SARS-CoV-2 Infection: A Meta-Analysis’. Diagnostics 2020 10(5):319. doi: 10.3390/diagnostics10050319, (Οι δυο πρώτοι συγγραφείς συμμετείχαν εξίσου) 

A15.    Vennou KE, Kontou PI, Braliou GG, Bagos PG. ‘Meta-analysis of gene expression profiles in preeclampsia’. Pregnancy Hypertens. 2020 19:52-60. doi: 10.1016/j.preghy.2019.12.007.  (ΙF: 2.622), (C:3).

A16.    Pappa SA, Kontou PI, Bagos PG, Braliou GG. ‘Urine-Based Molecular Diagnostic Tests for Leishmaniasis Infection in Human and Canine Populations: A Meta-Analysis’. Pathogens. 2021 10(3):269. doi: 10.3390/pathogens10030269.

A17.    Kontou, P., Pavlopoulou, A., Dimou, N., Theodoropoulou, M., Braliou, G., Tsaousis, G., … & Bagos, P. ‘The human GPCR signal transduction network. Network Modeling Analysis’ Health Informatics and Bioinformatics, (2021), 10(1), 1-12.

A18.   Barba E, Kontou PI, Michalopoulos I, Bagos PG and Braliou GG. ‘Association of ITPA gene polymorphisms with adverse effects of AZA/6-MP administration: a systematic review and meta-analysis’. The Pharmacogenomics Journal  2022, 22:35-54 doi: 10.1038/s41397-021-00255-3 

A19.    Tapari A, Braliou GG, Papaefthimiou M, Mavriki H, Kontou PI, Nikolopoulos GK, Pantelis PG. ’Performance of Antigen Detection Tests for SARS-CoV-2: A Systematic Review and Meta-Analysis’. Diagnostics (Basel). 2022, 12(6):1388., (Οι δυο πρώτοι συγγραφείς συμμετείχαν εξίσου) doi: 10.3390/diagnostics12061388

A20.    Charitou T, Kontou PI, Tamposis IA, Pavlopoulos GA, Braliou GG, Bagos PG. ‘Drug genetic associations with COVID-19 manifestations: a data mining and network biology approach’. Pharmacogenomics J. 2022 Sep 28:1-9. doi: 10.1038/s41397-022-00289-1.

Α21.    Petsana M, Roumia AF, Bagos PG, Boleti H, Braliou GG. ‘In Silico Identification and Analysis of Proteins Containing the Phox Homology Phosphoinositide-Binding Domain in Kinetoplastea Protists: Evolutionary Conservation and Uniqueness of Phox-Homology-Domain-Containing Protein Architectures’. Int J Mol Sci. 2023 Jul 15;24(14):11521. doi: 10.3390/ijms241411521.

Α22.   Papaefthimiou M, Kontou PI, Bagos PG, Braliou GG. ‘Antioxidant Activity of Leaf Extracts from Stevia rebaudiana Bertoni Exerts Attenuating Effect on Diseased Experimental Rats: A Systematic Review and Meta-Analysis’. Nutrients. 2023 Jul 26;15(15):3325. doi: 10.3390/nu15153325.

Α23.     Tegopoulos K, Fountas DV, Andronidou E, Bagos PG, Kolovos P, Skavdis G, Pergantas P, Braliou GG, Papageorgiou AC, Grigoriou ME. ‘Assessment of genetic diversity and population differentiation in wild hop (Humulus lupulus) from the Region of Central Greece by SNP-NGS genotyping’. Diversity. 2023, 15 (12),1171;  https://doi.org/10.3390/d15121171